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Difference between blood creatinine and urine creatinine

2018-03-19 08:00:00

The commonly used test in renal outpatient department is blood creatinine and urine creatinine. Generally speaking, creatinine refers to blood creatinine.


What is blood creatinine? Detection of serum creatinine is one of the most commonly used methods to understand renal function. So what about creatinine? Endogenous creatinine is the product of human muscle metabolism. In muscles, creatine slowly forms creatinine, mainly through an irreversible non-enzymatic dehydration reaction, which is then released into the blood and excreted in urine. Therefore, blood creatinine is closely related to the total amount of muscle in the body and is not easily affected by diet. Creatinine is a small molecule that can be filtered through the kidney/j, ball, and is rarely absorbed in the kidney, and almost all creatinine produced in the body is excreted with urine every day, generally not affected by urine volume. In renal insufficiency, creatinine accumulates in the body and becomes a harmful toxin. The normal upper limit for plasma creatinine is around 100 micromol/L.


What is urinary creatinine? Urine creatinine test can determine the creatinine content of blood excreted by renal filtration. Urinary creatinine concentration alone is rarely helpful in evaluating kidney function, but together with blood creatinine, it can be used as an essential indicator of endogenous creatinine clearance. The increase can be seen in acromegaly, gigantism, diabetes, infection, hypothyroidism, eating meat, exercise, and taking drugs (e.g., vitamin C, levodopa, methyldopa, etc.). Urinary creatinine reduction is seen in acute or chronic renal insufficiency, severe congestive heart failure, hyperthyroidism, anemia, muscular dystrophy, leukemia, vegetarians, and the use of androgens and thiazines.